Cytokine, Sickness Behavior, and Depression
نویسندگان
چکیده
منابع مشابه
Twenty years of research on cytokine-induced sickness behavior.
Cytokine-induced sickness behavior was recognized within a few years of the cloning and expression of interferon-alpha, IL-1 and IL-2, which occurred around the time that the first issue of Brain, Behavior, and Immunity was published in 1987. Phase I clinical trials established that injection of recombinant cytokines into cancer patients led to a variety of psychological disturbances. It was su...
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The innate immune receptor Toll-like 4 (TLR4) is the receptor activated by lipopolysaccharide (LPS), and TLR4-LPS interaction is well known to induce an innate immune response, triggering sickness behavior. Within the brain, TLR4 is highly expressed in brain microglia, and excessive inflammation resulting from activation of this pathway in the brain has been implicated in depressive disorders a...
متن کاملProinflammatory cytokines and sickness behavior: implications for depression and cancer-related symptoms.
PURPOSE/OBJECTIVES To review the relationship between proinflammatory cytokine release and resultant sickness behavior; to explore the implications of sickness behavior related to depression and cancer-related symptoms. DATA SOURCES Published articles and book chapters. DATA SYNTHESIS Proinflammatory cytokines (interleukin-1, interleukin-6, and tumor necrosis factor-alpha) are released as p...
متن کاملDepression and sickness behavior are Janus-faced responses to shared inflammatory pathways
It is of considerable translational importance whether depression is a form or a consequence of sickness behavior. Sickness behavior is a behavioral complex induced by infections and immune trauma and mediated by pro-inflammatory cytokines. It is an adaptive response that enhances recovery by conserving energy to combat acute inflammation. There are considerable phenomenological similarities be...
متن کاملSickness Behavior in Honey Bees
During an infection, animals suffer several changes in their normal physiology and behavior which may include lethargy, appetite loss, and reduction in grooming and general movements. This set of alterations is known as sickness behavior and although it has been extensively believed to be orchestrated primarily by the immune system, a relevant role for the central nervous system has also been e...
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ژورنال
عنوان ژورنال: Neurologic Clinics
سال: 2006
ISSN: 0733-8619
DOI: 10.1016/j.ncl.2006.03.003